Process analysis of fluidized bed granulation

@article{Rantanen2001ProcessAO,
  title={Process analysis of fluidized bed granulation},
  author={Jukka Rantanen and Anna Cecilia J\orgensen and Eetu R{\"a}s{\"a}nen and Pirjo Luukkonen and Sari Airaksinen and Johanna Raiman and Kaisa R H{\"a}nninen and Osmo Antikainen and Jouko K Yliruusi},
  journal={AAPS PharmSciTech},
  year={2001},
  volume={2},
  pages={13-20}
}
This study assesses the fluidized bed granulation process for the optimization of a model formulation using in-line near-infrared (NIR) spectroscopy for moisture determination. The granulation process was analyzed using an automated granulator and optimization of the verapamil hydrochloride formulation was performed using a mixture design. The NIR setup with a fixed wavelength detector was applied for moisture measurement. Information from other process measurements, temperature difference… CONTINUE READING