Process Development Strategies in Plant Molecular Farming.

@article{Buyel2015ProcessDS,
  title={Process Development Strategies in Plant Molecular Farming.},
  author={Johannes F Buyel},
  journal={Current pharmaceutical biotechnology},
  year={2015},
  volume={16 11},
  pages={966-82}
}
Protein-based biopharmaceuticals are often produced in mammalian cell cultures, which are more expensive than microbial systems but capable of authentic post-translational modifications. The costs are lower if plants are used as an alternative platform to produce complex proteins such as monoclonal antibodies, vaccines and enzymes. This review highlights recent advances that have been achieved in plant-based biopharmaceutical production platforms in terms of expression strategies, product… CONTINUE READING
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