Procentriole assembly revealed by cryo-electron tomography.

  title={Procentriole assembly revealed by cryo-electron tomography.},
  author={Paul Guichard and Denis Chr{\'e}tien and Sergio Di Marco and A. L. Tassin},
  journal={The EMBO journal},
  volume={29 9},
Centrosomes are cellular organelles that have a major role in the spatial organisation of the microtubule network. The centrosome is comprised of two centrioles that duplicate only once during the cell cycle, generating a procentriole from each mature centriole. Despite the essential roles of centrosomes, the detailed structural mechanisms involved in centriole duplication remain largely unknown. Here, we describe human procentriole assembly using cryo-electron tomography. In centrosomes… CONTINUE READING