Proceedings: Testicular feminization: studies of the molecular basis of a genetic defect.

@article{Bardin1974ProceedingsTF,
  title={Proceedings: Testicular feminization: studies of the molecular basis of a genetic defect.},
  author={C. Bardin and L. Bullock},
  journal={The Journal of investigative dermatology},
  year={1974},
  volume={63 1},
  pages={
          75-84
        }
}
Testicular feminization is an inherited disorder which is transmitted by some women to half their male offspring. The affected individuals are genetic males with end organ insensitivity to endogenous and exogenous androgens. As a consequence, they lack androgen-dependent differentiation and present clinically as phenotypic females with primary amenorrhea. Testicular feminization has also been described in the rat and the mouse. Studies on these rodents indicate that a major tissue abnormality… Expand
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