Procedural learning in Parkinson's disease and cerebellar degeneration
@article{PascualLeone1993ProceduralLI,
title={Procedural learning in Parkinson's disease and cerebellar degeneration},
author={{\'A}lvaro Pascual-Leone and Jordan Henry Grafman and K. Clark and M Stewart and Steve G. Massaquoi and J S Lou and Mark Hallett},
journal={Annals of Neurology},
year={1993},
volume={34}
}We compared procedural learning, translation of procedural knowledge into declarative knowledge, and use of declarative knowledge in age‐matched normal volunteers (n = 30), patients with Parkinson's disease (n = 20), and patients with cerebellar degeneration (n = 15) by using a serial reaction time task. Patients with Parkinson's disease achieved procedural knowledge and used declarative knowledge of the task to improve performance, but they required a larger number of repetitions of the task…
469 Citations
Procedural Memory in Recent-Onset Parkinson’s Disease
- Psychology, BiologyDementia and Geriatric Cognitive Disorders
- 1999
The aim of this study was to better define the characteristics of procedural memory by trying to determine the level of involvement of that memory in the acquisition process, then by specifying the effect of the type of resource involved (verbal or motor).
Dissociation of Habit-Learning in Parkinson's and Cerebellar Disease
- Psychology, BiologyJournal of Cognitive Neuroscience
- 2002
The probabilistic learning task is an implicit, nonmotor learning task which is sensitive for basal ganglia pathology but remains unaffected in the case of cerebellar pathology.
Motor procedural learning in Parkinson's disease.
- Psychology, BiologyBrain : a journal of neurology
- 2007
Procedural learning impairment is not an early feature of PD, but is likely to emerge with progression of the disease, independently of cognitive dysfunction or dopaminergic medication.
Procedural learning and striatofrontal dysfunction in Parkinson's disease
- Psychology, BiologyMovement disorders : official journal of the Movement Disorder Society
- 2002
Results confirm the involvement of striatofrontal circuits in procedural learning and indicate that the intervention of the frontal network may depend on the characteristics of the task.
Patients with Parkinson's disease learn to control complex systems via procedural as well as non-procedural learning
- Psychology, BiologyNeuropsychologia
- 2008
Neurological basis of skill learning.
- Psychology, BiologyBrain research. Cognitive brain research
- 1996
Procedural motor learning in Parkinson's disease
- Psychology, BiologyExperimental Brain Research
- 2001
The hypothesis that deficiencies in procedural motor learning are characteristic of Parkinson's disease is supported, adding to existing evidence which has suggested a key role for the basal ganglia when new sensorimotor mappings are required by novel task environments.
Selective impairments in implicit learning in Parkinson's disease
- Psychology, BiologyBrain Research
- 2007
Visuo-motor and cognitive procedural learning in children with basal ganglia pathology
- Psychology, MedicineNeuropsychologia
- 2010
Motor Skill Learning, Retention, and Control Deficits in Parkinson's Disease
- Psychology, BiologyPloS one
- 2011
The intact ability to learn a novel motor skill in non-demented, medicated patients with Parkinson's disease is demonstrated and confounding effects of motor control deficits on retention performance are indicated.
References
SHOWING 1-10 OF 46 REFERENCES
Procedural memory in Parkinson's disease: impaired motor but not visuoperceptual learning.
- Psychology, BiologyJournal of clinical and experimental neuropsychology
- 1990
The results showed that PD patients were not impaired on mirror reading or paired associate learning, and the underlying processes/procedures for procedural learning are specific to the task, and are supported by different neuroanatomical systems.
Procedural learning and neostriatal dysfunction in man.
- Psychology, BiologyBrain : a journal of neurology
- 1988
Patients with early stage Parkinson's disease are shown to be selectively impaired in a cognitive task of procedural learning while remaining intact in recall and recognition tests of declarative memory, thus demonstrating a double dissociation.
Implicit learning in patients with Alzheimer's disease.
- Psychology, BiologyPharmacopsychiatry
- 1990
It is found that DAT patients demonstrated marginal but significant implicit learning on both procedural learning and perceptual priming tasks, suggesting that priming of meaningful stimuli is subserved by cortical structures whereas procedural motor responses to simple serial visual stimulus patterns can be maintained by subcortical systems.
Cognition and the Basal Ganglia: A Possible Substrate for Procedural Knowledge
- Psychology, BiologyCanadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
- 1987
A brief review emphasizes the distinction between procedural and declarative knowledge and examines the possible role of the basal ganglia in the acquisition and retention of procedural knowledge.
Cognitive planning deficit in patients with cerebellar atrophy
- PsychologyNeurology
- 1992
Neither age, sex, education level, severity of dementia, word fluency, response time, memory, nor visuomotor procedural learning predicted CA or CCA performance, but a deficit in cognitive planning suggests a functional link between the cerebellum, basal ganglia, and the frontal lobe concerning specific cognitive processes.
Procedural learning is impaired in Huntington's disease: Evidence from the serial reaction time task
- Psychology, BiologyNeuropsychologia
- 1991
On the development of procedural knowledge.
- Biology, Psychology
- 1989
A subgroup of subjects showed substantial procedural learning of the sequence in the absence of explicit declarative knowledge of it, and their ability to generate the sequence was effectively at chance and showed no savings in learning.
The role of cerebellar structures in the execution of serial movements.
- Psychology, BiologyBrain : a journal of neurology
- 1989
The hypothesis that the translation of a programmed sequence of responses into action involves cerebellar structures which schedule a sequence of ordered responses before onset of movement is supported.
Implicit learning in patients with probable Alzheimer's disease
- Psychology, BiologyNeurology
- 1987
Patients with probable Alzheimer's disease and elderly control subjects were given a serial visual reaction time task with an embedded repeating sequence and patients who failed to learn the sequence were similar in age and overall severity of dementia to those who learned.