Procedural learning and striatofrontal dysfunction in Parkinson's disease

  title={Procedural learning and striatofrontal dysfunction in Parkinson's disease},
  author={Marie Sarazin and Bernard Deweer and Angela Merkl and Natalia Von Poser and Bernard Pillon and Bruno Dubois},
  journal={Movement Disorders},
The neural basis of procedural learning remains controversial. We further analyzed procedural learning in nondemented patients with Parkinson's disease (PD) according to the specific demands of the tasks and the severity of striatal and frontal lobe dysfunction. In the first experiment, the performance of 20 nondemented PD patients and matched normal control subjects was studied in two procedural learning tasks, rotor pursuit and mirror reading, that differ in terms of motor and cognitive… 

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