Procathepsin D secreted by HaCaT keratinocyte cells - A novel regulator of keratinocyte growth.

@article{Vashishta2007ProcathepsinDS,
  title={Procathepsin D secreted by HaCaT keratinocyte cells - A novel regulator of keratinocyte growth.},
  author={Aruna Vashishta and Sujata Saraswat Ohri and Jana Větvi{\vc}kov{\'a} and Martin Fusek and Jitka Ulrichov{\'a} and Vaclav Vetvicka},
  journal={European journal of cell biology},
  year={2007},
  volume={86 6},
  pages={
          303-13
        }
}
Procathepsin D (pCD), the precursor form of lysosomal aspartic protease, is overexpressed and secreted by various carcinomas. The fact that secreted pCD plays an essential role in progression of cancer has been established. In this study, we describe substantial secretion of pCD by the human keratinocyte cell line HaCaT, under serum-free conditions. Moreover, exogenous addition of purified pCD enhanced the proliferation of HaCaT cells. The proliferative effect of pCD was inhibited by a… CONTINUE READING
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