Procaspase 8 overexpression in non-small-cell lung cancer promotes apoptosis induced by FLIP silencing

@article{Wilson2009Procaspase8O,
  title={Procaspase 8 overexpression in non-small-cell lung cancer promotes apoptosis induced by FLIP silencing},
  author={Timothy Richard Wilson and Kelly Marie Redmond and Kirsty M McLaughlin and Nyree T. Crawford and Kathy Gately and Ken O'Byrne and C Le-Clorrenec and Caitriona Holohan and D. A. Fennell and Patrick Gerard Johnston and Daniel Broderick Longley},
  journal={Cell Death and Differentiation},
  year={2009},
  volume={16},
  pages={1352-1361}
}
We found that procaspase 8 was overexpressed in non-small-cell lung cancers (NSCLCs) compared with matched normal tissues. The caspase 8 inhibitor FLICE-inhibitory protein (FLIP) was also overexpressed in the majority of NSCLCs. Silencing FLIP induced caspase 8 activation and apoptosis in NSCLC cell lines, but not in normal lung cell lines. Apoptosis induced by FLIP silencing was mediated by the TRAIL death receptors DR4 and DR5, but was not dependent on ligation of the receptors by TRAIL… CONTINUE READING
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