Procarbazine in haematology: an old drug with a new life?

  title={Procarbazine in haematology: an old drug with a new life?},
  author={Marcel Massoud and Jean Pierre Armand and Vincent Ribrag},
  journal={European journal of cancer},
  volume={40 13},
Procarbazine (PCB) was developed in the 1960s and was rapidly recognised as an active agent in lymphoid malignancies. PCB was one of the four drugs combined in mechlorethamine, vincristine, PCB, prednisolone (MOPP), one of the first combination chemotherapy regimens to show that advanced-stage disease could be cured in humans. During the last few decades, comprehensive studies have clarified cellular pathways involved in the modes of action of PCB and its drug resistance mechanisms. However… CONTINUE READING

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