Procalcitonin for the clinical laboratory: a review

@article{Schneider2007ProcalcitoninFT,
  title={Procalcitonin for the clinical laboratory: a review},
  author={Hans Gerhard Schneider and Q T Lam},
  journal={Pathology},
  year={2007},
  volume={39},
  pages={383–390}
}
&NA; Procalcitonin measurement has been claimed as a helpful marker in bacterial infection and sepsis. It has obtained FDA approval and is now widely marketed in the United States and Europe. This review summarises the current assays available, the evidence for its use and possible future applications of the assay. 
Procalcitonin-guided treatment of lower respiratory tract infections
TLDR
The use of procalcitonin testing and evidence-based medical decision-making for patients with sepsis or lower respiratory tract infections is reviewed.
Procalcitonin Use in a Pediatric Intensive Care Unit
TLDR
Data suggest PCT can assist in identifying patients without serious bacterial infections and limit antimicrobial use, and suggest it should be limited in clinical practice.
Can Procalcitonin in Cerebrospinal Fluid be a Diagnostic Tool for Meningitis?
To study the levels of procalcitonin (PCT) in patients with meningitis and control group and compare them with established markers of infection—such as C‐reactive protein (CRP), high‐sensitivity CRP,
Procalcitonin; appraisal of a useful tool for antimicrobial therapy-a chemical pathologist’s perspective
TLDR
The utility of Procalcitonin (PCT) carries a lot of associated benefits which include reduction in misuse of antibiotics with the consequent outcome of antibiotic resistance, lesser cost of care, decrease in hospital stay and overall morbidity and mortality.
Meta-analysis: Procalcitonin-guided antibiotic therapy reduces treatment failure in acute respiratory infection
Source Citation Schuetz P, Muller B, Christ-Crain M, et al. Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections. Cochrane Database Syst Rev. 2012;(9):CD007498...
Procalcitonin: Uses in the Clinical Laboratory for the Diagnosis of Sepsis
TLDR
The current knowledge of PCT and its use in the clinical laboratory setting is reviewed and it is shown that PCT is a biomarker that exhibits greater specificity than other proinflammatory markers in identifying patients with sepsis and can be used in the diagnosis of bacterial infections.
Application of Procalcitonin in Gout Disease
  • Tian Li
  • 2021
Gout is a chronic disease with urate crystal deposition as its main pathological feature, which belongs to metabolic rheumatism. Serum Procalcitonin (PCT) is a soluble protein in the circulatory
Review Article: Procalcitonin in sepsis and bacterial infections
TLDR
PCT is considered a reliable marker for the diagnosis and prognosis of moderate to severe bacterial infections, and it has also been evaluated to guide the clinicians in the rational usage of antibiotics.
Is serum procalcitonin measurement a useful addition to a rheumatologist's repertoire? A review of its diagnostic role in systemic inflammatory diseases and joint infections.
TLDR
PCT when used in the appropriate clinical setting can be a useful adjunct to currently available laboratory infection markers, though further studies are warranted.
Procalcitonin, C‐reactive protein, and presepsin for the diagnosis of sepsis in adults and children
TLDR
Procalcitonin, C-reactive protein, and presepsin for the diagnosis of sepsis in adults and children and the Cochrane Database of Systematic Reviews, 4:1-15, April 2017.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 84 REFERENCES
Procalcitonin and neopterin as indicators of infection in critically ill patients
TLDR
Both procalcitonin and neopterin have been suggested to aid in the early diagnosis of bacterial infections and in differentiating bacterial infections from systemic inflammatory, non‐infectious diseases or from viral infections.
Potential use of procalcitonin as a diagnostic criterion in febrile neutropenia: experience from a multicentre study.
TLDR
It was concluded that procalcitonin is a marker strongly suggestive of severe sepsis at concentrations of > 5.0 ng/mL, and it was observed that bacteraemia associated with coagulase-negative staphylococci may fail to elevate serum procalCitonin levels.
Procalcitonin in bacterial infections--hype, hope, more or less?
TLDR
This review aims to help the clinician to understand the physiopathological basis, to appreciate strengths and weaknesses of this biomarker, and thereby to promote a rational implementation of ProCT in a routine setting.
Biological variation of procalcitonin in healthy individuals.
TLDR
The results of a study to determine the biological variation of PCT are reported, which shows high serum concentrations have been reported in patients with severe systemic bacterial or fungal, but not viral, infections.
Procalcitonin: A Marker of Bacteraemia in SIRS
TLDR
Measurement of PCT alone or in combination with CRP can aid discrimination of septicaemia/bacteraemia with associated SIRS from non-infectious SirS in an Australian ICU setting, while PCT was a more accurate diagnostic test for bacteraemia than CRP.
Usefulness of procalcitonin in neonates at risk for infection.
TLDR
This report confirms and extends previous work on the daily variations of PCT during the first days of life in noninfected newborn infants and agrees that PCT could be a useful marker for the presence, course, and prognosis of bacterial infection.
Detection of procalcitonin (PCT) in healthy controls and patients with local infection by a sensitive ILMA.
TLDR
First results indicate that the new PCT assay is suitable to differentiate local bacterial infections from other non-infectious diseases and allowing for the first time PCT detection in healthy individuals.
Bedside procalcitonin and C-reactive protein tests in children with fever without localizing signs of infection seen in a referral center.
TLDR
PCT and CRP performed better than IL-6, WBC, and/or band count in predicting the occurrence of SBI and should be considered in the initial work-up of children with fever without source.
DIAGNOSTIC VALUE OF SERUM PROCALCITONIN AND C-REACTIVE PROTEIN IN EGYPTIAN CHILDREN WITH STREPTOCOCCAL TONSILLOPHARYNGITIS
We investigated serum procalcitonin (PCT) and C-reactive protein (CRP) in children with streptococcal tonsillopharyngitis or nonstreptococcal tonsillopharyngitis and in healthy children. The median
Procalcitonin: a marker to clearly differentiate systemic inflammatory response syndrome and sepsis in the critically ill patient?
TLDR
The definite differential diagnosis between SIRS and sepsis may not rely on a single application of procalcitonin but on the complete clinical and laboratory evaluation of the patient with procalCitonin playing a considerable role.
...
1
2
3
4
5
...