Procaine effects on sodium and chloride transport in frog skin

@article{Flonta1988ProcaineEO,
  title={Procaine effects on sodium and chloride transport in frog skin},
  author={Maria-Luiza Flonta and Wiltraud Endstrasser and Inge Kirmeyer and Wolfram Nagel},
  journal={Pfl{\"u}gers Archiv},
  year={1988},
  volume={411},
  pages={386-393}
}
Procaine, a tertiary amine, has previously been shown to stimulate reversibly transepithelial Na transport across frog skin after application from the epithelial side. In the present study with intracellular recording from principal, i.e. amiloride-sensitive cells, we demonstrate that the stimulation results from increase in apical membrane Na permeability. A second effect of procaine (10–25 mmol/l) in the outside perfusion solution is a reversible increase of transepithelial conductance which… CONTINUE READING
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