Procaine and mepivacaine have less toxicity in vitro than other clinically used local anesthetics.

@article{Kasaba2003ProcaineAM,
  title={Procaine and mepivacaine have less toxicity in vitro than other clinically used local anesthetics.},
  author={Toshiharu Kasaba and Shin Onizuka and Mayumi Takasaki},
  journal={Anesthesia and analgesia},
  year={2003},
  volume={97 1},
  pages={85-90, table of contents}
}
UNLABELLED The neurotoxicity of local anesthetics can be demonstrated in vitro by the collapse of growth cones and neurites in cultured neurons. We compared the neurotoxicity of procaine, mepivacaine, ropivacaine, bupivacaine, lidocaine, tetracaine, and dibucaine by using cultured neurons from the freshwater snail Lymnaea stagnalis. A solution of local anesthetics was added to the culture dish to make final concentrations ranging from 1 x 10(-6) to 2 x 10(-2) M. Morphological changes in the… CONTINUE READING

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