Probucol inhibits oxidative modification of low density lipoprotein.

  title={Probucol inhibits oxidative modification of low density lipoprotein.},
  author={Sampath Parthasarathy and Stephen G. Young and Joseph L. Witztum and Russ Pittman and Daniel Steinberg},
  journal={The Journal of clinical investigation},
  volume={77 2},
Previous studies have established that low density lipoprotein (LDL) incubated with endothelial cells (EC) undergoes extensive oxidative modification in structure and that the modified LDL is specifically recognized by the acetyl LDL receptor of the macrophage. Thus, in principle, EC-modified LDL could contribute to foam cell formation during atherogenesis. Oxidatively modified LDL is also potentially toxic to EC. The present studies show that addition of probucol during the incubation of LDL… CONTINUE READING
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