Problems with long-term levodopa therapy for Parkinson's disease.

@article{Marsden1994ProblemsWL,
  title={Problems with long-term levodopa therapy for Parkinson's disease.},
  author={C. David Marsden},
  journal={Clinical neuropharmacology},
  year={1994},
  volume={17 Suppl 2},
  pages={S32-44}
}
The introduction of levodopa 25 years ago revolutionized the management of Parkinson's disease. However, it soon became apparent that the drug offered only symptomatic relief and did not affect the underlying pathology. Moreover, chronic use of the drug was associated with a range of adverse effects. Current therapeutic strategies seek to delay long-term… CONTINUE READING