Problems of multiplicity in clinical trials

@inproceedings{Simon1994ProblemsOM,
  title={Problems of multiplicity in clinical trials},
  author={Richard Simon},
  year={1994}
}
Abstract Most of the uncertainties in the conclusions of randomized clinical trials results either from inadequate sample size or from problems of multiplicity. Problems of multiplicity result from the testing of multiple hypotheses or the testing of a hypothesis at multiple points in time or in multiple ways. I review several common problems of this type: multiple analyses of accumulating data, analyses of multiple endpoints, multiple subsets of patients, multiple treatment group contrasts and… CONTINUE READING

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