Problems of classification of Henoch Schonlein purpura: an Indian perspective

  title={Problems of classification of Henoch Schonlein purpura: an Indian perspective},
  author={Narayana S. Murali and Robin George and George Tharayil John and Sushil M. Chandi and Mary Jacob and Lakshmanan Jeyaseelan and Paulose P Thomas and Chakko Korula Jacob},
  journal={Clinical and Experimental Dermatology},
Summary A 2‐year prospective study was carried out in which 71 patients with primary cutaneous vasculitis were classified using the American College of Rheumatology (ACR) classification and the Chapel Hill Consensus Conference (CHCC) recommendations for Henoch Schonlein purpura (HSP). The sensitivity of the ACR criteria was 64.8% and that of the CHCC definition 31%. When the ACR criteria were combined with results of direct immunofluorescence (DIF) the sensitivity was 78.9%. The concordance… 

Problems in classifying vasculitis in children

  • S. Ozen
  • Medicine
    Pediatric Nephrology
  • 2005
Paediatricians should revise the existing criteria based on registries and international consensus in the field to avoid problems with misclassification and a low concordance between the two criteria.

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HSP is a distinctive self-limited disorder, typically occurring during the autumn and winter months in children, thought to occur more often in female children, although some have found a male predominance or both sexes to be equally affected.

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Taking together the clinical signs, the laboratory markers, and the ultrasound findings, Henoch-Schönlein purpura can mimic acute cholecystitis and should be considered as a rare differential diagnosis of acute CholecyStitis.

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Current knowledge of the epidemiology, pathogenesis, principal manifestations, investigation and evidence-based management, extrapolated from adult studies, of the ANCA-associated disorders is summarized.

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A case of HSP with an intracerebral hemorrhage in a 67-year-old female who was diagnosed with HSP and complained of left homonymous hemianopsia and numbness in the right hand during treatment is described.

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Cutaneous vasculitis in a defined population--clinical and epidemiological associations.

The ACR 1990 criteria for HSP and HSV overlap; the Chapel Hill Consensus Conference definition of cutaneous leukocytoclastic angiitis and HSP provide clearer distinction.

Prognostic factors in leukocytoclastic vasculitis: a clinicopathologic study of 160 patients.

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Nomenclature of systemic vasculitides. Proposal of an international consensus conference.

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Cutaneous vasculitis.

  • D. Fiorentino
  • Medicine
    Journal of the American Academy of Dermatology
  • 2003
The classification and diagnosis of cutaneous vasculitic syndromes and current treatment options are reviewed and a comprehensive approach to diagnosing and treating the patient with suspected cutaneous Vasculitis is presented.

IgA1 is the major IgA subclass in cutaneous blood vessels in Henoch–Schönlein purpura

IgA1 is the dominant IgA subclass found in the skin in Henoch–Schönlein purpura, and the subclass distribution of antibodies to this IgA was studied in the biopsies of 28 patients with HSP by direct immunofluorescence.

Cutaneous Leukocytoclastic Vasculitis Serial Histopathologic Evaluation Demonstrates the Dynamic Nature of the Infiltrate

A patient with a cutaneous leukocytoclastic vasculitis manifest as palpable purpura had four lesions encircled on the day of presentation and the character of the infiltrate progressively changed from a neutrophilic-Predominant to a mononuclear-predominant infiltrate supporting the theory of a dynamic process in cutaneous vasculopathy.

Impaired neutrophil functions in patients with leukocytoclastic vasculitis

Leukocytoclastic vasculitis is considered to be related to a type III hypersensitivity reaction, although the exact etiologic mechanism is not clear.

American College of Rheumatology.

  • A. Gibofsky
  • Medicine
    Journal of the Medical Association of Georgia
  • 2002
Rheumatologists who have obtained training and certification in musculoskeletal ultrasound should receive fair, timely, reasonable reimbursement for their musculo- skeletal ultrasound services.