Problems in differentiating SLE and mixed connective-tissue disease.

@article{Reichlin1976ProblemsID,
  title={Problems in differentiating SLE and mixed connective-tissue disease.},
  author={Morris Reichlin},
  journal={The New England journal of medicine},
  year={1976},
  volume={295 21},
  pages={
          1194-5
        }
}

• Morris Reichlin
• Published in
  The New England journal of…
  1976
• DOI:10.1056/NEJM197611182952112

Although the nature of systemic lupus erythematosus still poses many mysteries, substantial progress has been made in defining specific autoantigens reactive with the serum of patients with this disease.1 Foremost among the antinuclear antibodies, the presence of antibodies to native DNA correlates, with rare exception, with the clinical diagnosis. These antibodies to DNA are of more than diagnostic interest since the cumulative evidence is strong that the DNA-anti-DNA system is the major… CONTINUE READING

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