Problems and pitfalls in grading of bone marrow fibrosis, collagen deposition and osteosclerosis - a consensus-based study.

@article{Kvasnicka2016ProblemsAP,
  title={Problems and pitfalls in grading of bone marrow fibrosis, collagen deposition and osteosclerosis - a consensus-based study.},
  author={Hans Michael Kvasnicka and Christine Beham-Schmid and Roshanak Bob and Stephan R Dirnhofer and Kais Hussein and Hans Kreipe and Markus Kremer and Annette Schmitt-Graeff and Stephan Schwarz and Juergen Michael Thiele and Martin Werner and Harald Von Stein},
  journal={Histopathology},
  year={2016},
  volume={68 6},
  pages={905-15}
}
AIMS In the era of potentially disease-modifying agents such as Janus kinase inhibitors, accurate grading and differentiation of bone marrow (BM) fibrosis has become more relevant to assess staging of disease and therapeutic effects. However, different fibrosis grading models have been used in the past without uniformity, including the proposal by the World Health Organization. Current scoring systems are based only on reticulin fibrosis. Therefore, additional assessment of collagen and the… CONTINUE READING
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