Problems and challenges in the design of irritable bowel syndrome clinical trials: experience from published trials.

@article{Spiller1999ProblemsAC,
  title={Problems and challenges in the design of irritable bowel syndrome clinical trials: experience from published trials.},
  author={Robin C Spiller},
  journal={The American journal of medicine},
  year={1999},
  volume={107 5A},
  pages={91S-97S}
}
The last two decades have seen many studies that are of inadequate design and power. This report focuses on what we have learned from the 25 randomized, controlled studies that included at least 30 patients during the period 1976-1998. The most important finding has been that the median placebo response was 47% (range, 0-84%), which is approximately three times the size of the difference between placebo and drug response, median 16% (range, -17-64%). This tells us the importance of reassurance… CONTINUE READING

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