Problematic proctitis and distal colitis

@article{Gionchetti2004ProblematicPA,
  title={Problematic proctitis and distal colitis},
  author={Paolo Gionchetti and Fernando Rizzello and Claudia Morselli and Massimo Campieri},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2004},
  volume={20}
}
About two‐thirds of patients with ulcerative colitis have an inflammatory involvement distal to the splenic flexure, and therefore may be effectively treated with topical treatment, allowing the delivery of the active drug directly to the site of inflammation and limiting systemic absorption and potential side‐effects. Topical aminosalicylate therapy is the most effective approach, and most patients will benefit hugely, provided that the formulation reaches the upper extent of the disease… 
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