Probiotics up-regulate MUC-2 mucin gene expression in a Caco-2 cell-culture model

@article{Mattar2002ProbioticsUM,
  title={Probiotics up-regulate MUC-2 mucin gene expression in a Caco-2 cell-culture model},
  author={Aladdein F Mattar and Daniel Teitelbaum and Robert A. Drongowski and F. Yongyi and Caroll M. Harmon and Arnold G. Coran},
  journal={Pediatric Surgery International},
  year={2002},
  volume={18},
  pages={586-590}
}
Enteral probiotics such as Lactobacillus casei GG (LGG) have been used in the treatment of a variety of intestinal disorders in infants and children, including diarrhea, malabsorption, and Clostridium difficile colitis. Previous studies have identified the gene locus for mucin (MUC-2) and its expression in Caco-2 cells. Others have demonstrated that mucin, located on the surface of the intestinal epithelium, inhibits bacterial translocation (BT). We previously demonstrated that both mucin and… CONTINUE READING