Probiotics prevent necrotizing enterocolitis by modulating enterocyte genes that regulate innate immune-mediated inflammation.

@article{Ganguli2013ProbioticsPN,
  title={Probiotics prevent necrotizing enterocolitis by modulating enterocyte genes that regulate innate immune-mediated inflammation.},
  author={Kriston Ganguli and Di Meng and Samuli Rautava and Lei Lu and W. A. Walker and N. Nanda Nanthakumar},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2013},
  volume={304 2},
  pages={G132-41}
}
Necrotizing enterocolitis (NEC), an extensive intestinal inflammatory disease of premature infants, is caused, in part, by an excessive inflammatory response to initial bacterial colonization due to the immature expression of innate immune response genes. In a randomized placebo-controlled clinical trial, supplementation of very low birth weight infants with probiotics significantly reduced the incidence of NEC. The primary goal of this study was to determine whether secreted products of these… CONTINUE READING
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Probiotics prevent necrotizing enterocolitis by modulating enterocyte genes that regulate innate immune - mediated inflammation

  • WA Walker
  • Am J Physiol Gastrointest Liver Physiol
  • 2013

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