Probiotics potentiate IL-6 production in IL-1beta-treated Caco-2 cells through a heat shock-dependent mechanism.

@article{Reilly2007ProbioticsPI,
  title={Probiotics potentiate IL-6 production in IL-1beta-treated Caco-2 cells through a heat shock-dependent mechanism.},
  author={Natasha Reilly and Vitaliy Y. Poylin and Michael J Menconi and Andrew O Onderdonk and Stig Bengmark and Per Olof Hasselgren},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2007},
  volume={293 3},
  pages={R1169-79}
}
IL-6 may exert anti-inflammatory and protective effects in intestinal mucosa and enterocytes. The influence of probiotics on mucosal and enterocyte IL-6 production is not known. We tested the hypothesis that the probiotic bacteria Lactobacillus paracasei and Lactobacillus plantarum regulate IL-6 production in intestinal epithelial cells. Cultured Caco-2 cells were treated with 1 ng/ml of IL-1beta in the absence or presence of different concentrations of L. paracasei or L. plantarum followed by… CONTINUE READING

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