Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial

@article{Kalliomki2001ProbioticsIP,
  title={Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial},
  author={Marko Kalliom{\"a}ki and Seppo Salminen and Heikki S Arvilommi and Pentti O. Kero and Pertti J Koskinen and Erika Isolauri},
  journal={The Lancet},
  year={2001},
  volume={357},
  pages={1076-1079}
}

Figures and Tables from this paper

PANDA STUDY Probiotics AND Allergy Primary prevention of asthma and allergy by supplementation of probiotics in early life

  • Biology
  • 2015
Exposure of pregnant women with previous or recent atopic disease, and their offspring to probiotics has been suggested, and it is likely that antigen-presenting cells (APC's) are involved, since these cells are important in the first line of defence in the gastrointestinal tract.

Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial

Maternal probiotic ingestion alone may be sufficient for long term reduction in the cumulative incidence of AD, but not other allergy related diseases.

Atopic dermatitis and skin disease A differential effect of 2 probiotics in the prevention of eczema and atopy : A double-blind , randomized , placebo-controlled trial

A double-blind, randomized placebo-controlled trial of infants at risk of allergic disease to determine whether probiotic supplementation in early life could prevent development of eczema and atopy at 2 years.

Probiotics: on-going research on atopic individuals

The regulatory role of probiotics in human allergic disease was first emphasised in the demonstration of a suppressive effect on lymphocyte proliferation and interleukin-4 generation in vitro, and a significant improvement in the clinical course of atopic eczema was reported in infants given a probiotic-supplemented diet.

Probiotics in the Treatment and Prevention of Allergies in Children

It is inferred that probiotics induce systemically detectable low-grade inflammation, which may explain the clinical effects and the secretion pattern of cytokines induced by PBMC, andications from studies of feces and blood at the age 6 months suggest that probiotic may enhance both inflammation and immune defence of the gut.

Probiotics in the Treatment and Prevention of Allergy in Children

Results on randomized, controlled studies in which childhood atopic eczema was treated or which aimed to prevent development of allergy during childhood are reported.

Probiotics in the atopic march: highlights and new insights.

  • M. M. del GiudiceA. RoccoC. Capristo
  • Biology
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2006

Probiotic bacteria for prevention of atopic diseases: design and application

Results from the Panda study suggest that probiotic bacteria modulate the developing immune system but long term effects should be investigated in future studies, as the preventive effect appeared to be established within the first three months of life.

Probiotic Bacteria in the Management of Atopic Disease: Underscoring the Importance of Viability

Assessment of the efficacy of oral supplementation of viable and heat-inactivated probiotic bacteria in the management of atopic disease and their effects on the composition of the gut microbiota found them to be a potential approach for the management for atopic eczema and cow's milk allergy.

Probiotics in Allergic Diseases

Probiotic interventions administered during pregnancy and breastfeeding offer a unique opportunity to influence a range of important maternal and infant outcomes.
...

References

SHOWING 1-10 OF 112 REFERENCES

Probiotics in primary prevention of atopic disease: a randomised placebo‐controlled trial.

Gut microflora might be a hitherto unexplored source of natural immunomodulators and probiotics, for prevention of atopic disease in children at high risk.

Probiotics: a novel approach in the management of food allergy.

Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing.

Differences in the neonatal gut microflora precede the development of atopy, suggesting a crucial role of the balance of indigenous intestinal bacteria for the maturation of human immunity to a nonatopic mode.

Impact of Dietary Yogurt on Immune Function

The consumption of yogurt that contained the live active bacteria L bulgaricus and S thermophilus does not appear to enhance immune function in atopic individuals at the dosage and duration used in this study.

Atopic diseases in infancy. The German multicenter atopy study (MAS‐90)

  • R. BergmannK. Bergmann U. Wahn
  • Medicine
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 1994
The German Multicenter Atopy Study (MAS-90) was initiated to evaluate the predictive value of various clinical and immunological parameters as well as the significance of early environmental exposures to allergens and trigger factors for the development of atopic diseases in early childhood.

Immune and clinical impact of Lactobacillus acidophilus on asthma.

  • J. G. WheelerS. Shema R. Helm
  • Medicine
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • 1997

Early childhood infection and atopic disorder

Interpretation of the prediction of atopic disorders by immunisation with whole-cell pertussis vaccine and treatment with oral antibiotics needs to be very cautious because of the possibilities of confounding effects and reverse causation.

Allergy development and the intestinal microflora during the first year of life.

Differences in the composition of the gut flora between infant who will and infants who will not develop allergy are demonstrable before the development of any clinical manifestations of atopy.
...