Probiotics in pregnancy and maternal outcomes: a systematic review

@article{Lindsay2013ProbioticsIP,
  title={Probiotics in pregnancy and maternal outcomes: a systematic review},
  author={Karen L. Lindsay and Colin A Walsh and Lorraine Brennan and Fionnuala M Mcauliffe},
  journal={The Journal of Maternal-Fetal \& Neonatal Medicine},
  year={2013},
  volume={26},
  pages={772 - 778}
}
Abstract Objectives: To systematically review the literature on the use of probiotics in pregnancy and their impact on maternal outcomes. Methods: Online databases were searched in April 2012 using the following terms to identify eligible studies: “probiotics”, “pregnancy”, “maternal outcomes” and “metabolism”. Primary outcomes of selected studies were maternal fasting glucose during pregnancy and rates of gestational diabetes mellitus (GDM). Secondary outcomes were rates of pre-eclampsia… Expand

Paper Mentions

Interventional Clinical Trial
The randomized controlled trial (RCT) recruits pregnant women with de novo diagnosis of gestational diabetes. Women bearing a singleton pregnancy are randomized into four arms: DHA… Expand
ConditionsGestational Diabetes Mellitus in Pregnancy
InterventionDietary Supplement
Interventional Clinical Trial
Obesity is one of the most concerning health issues in the modern world, especially due to its association with greater risk of developing a wide range of chronic diseases. Pre… Expand
ConditionsInflammation, Obesity, Pregnancy
InterventionDietary Supplement
Probiotic treatment for women with gestational diabetes to improve maternal and infant health and well-being.
TLDR
The safety and effectiveness of probiotics in treating women with GDM on maternal and infant outcomes is evaluated and it is uncertain if probiotics have any effect, compared with placebo, on the risk of large-for-gestational-age babies or infant hypoglycaemia. Expand
Through the Microbial Looking Glass: Premature Labor, Preeclampsia, and Gestational Diabetes A Scoping Review
TLDR
The relationships between the microbiome and the risk for PEC, PTB, and GDM are not fully elucidated, although probiotic interventions seem beneficial in decreasing PEC and G DM risk. Expand
Probiotics for preventing gestational diabetes.
TLDR
One trial has shown a reduction in the rate of GDM when women are randomised to probiotics early in pregnancy but more uncertain evidence of any effect on miscarriage/IUFD/stillbirth/ stillbirth/neonatal death is uncertain. Expand
Acceptability of and compliance with a probiotic capsule intervention in pregnancy
  • K. Lindsay, L. Brennan, F. Mcauliffe
  • Medicine
  • International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 2014
TLDR
If further studies continue to find beneficial outcomes associated with probiotic use in pregnancy, recommendations for their general use are likely to be well-received by pregnant women, which may hold significant benefits for future clinical obstetric care. Expand
Probiotics for preventing gestational diabetes.
TLDR
It is uncertain if probiotics have any effect on the risk of GDM compared to placebo, and the CIs for hypertensive disorders of pregnancy also indicated probiotics may have no effect, but the evidence was low certainty due to substantial heterogeneity and wide CIs that included both appreciable benefit and appreciable harm. Expand
The impact of probiotic supplementation on metabolic health in healthy women of reproductive age: a systematic review.
TLDR
No conclusive evidence that probiotic capsule supplementation elicited positive effects in healthy, non-pregnant women of reproductive age was found, highlighting the need for further research to investigate the role that probiotics play during the pre-conception period, on female metabolic and immune health. Expand
Impact of probiotics in women with gestational diabetes mellitus on metabolic health: a randomized controlled trial.
TLDR
A probiotic capsule intervention among women with abnormal glucose tolerance had no impact on glycemic control and the observed attenuation of the normal pregnancy-induced rise in total and LDL cholesterol following probiotic treatment requires further investigation. Expand
The Effect of Probiotics or Synbiotics on the Hypertensive Disorders of Pregnant Women with Gestational Diabetes: A Systematic Review and Meta-analysis
TLDR
Probiotic or synbiotic supplements are not associated with significant effects on pregnancy outcomes in GDM, but due to the limited number of studies in this regard and heterogeneity between studies, future high-quality RCTs are recommended. Expand
Effects of probiotics (Vivomixx®) in obese pregnant women and their newborn: study protocol for a randomized controlled trial
TLDR
Investigating whether daily probiotic supplements in obese women during pregnancy can limit gestational weight gain, improve glucose homeostasis and thereby improve maternal, fetal and infant health outcomes to find alterations in the metabolic profiles, microbiota and possibly pregnancy outcomes. Expand
Multistrain Probiotic increase the Gut Microbiota Diversity in Obese Pregnant Women Results from a Randomized, Double-Blind Placebo-Controlled Study
Background: Maternal obesity is associated with adverse pregnancy outcomes. Probiotic supplementation during pregnancy may have positive effects on blood glucose, gestational weight gain (GWG), andExpand
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