Probiotics in clostridium difficile Infection.

  title={Probiotics in clostridium difficile Infection.},
  author={Xi Na and Ciaran Kelly},
  journal={Journal of clinical gastroenterology},
  volume={45 Suppl},
Clostridium difficile infection (CDI) is one of the most prevalent nosocomial infections. A dramatic increase in the incidence and severity of CDI has been noted in the past decade. Current recommendations suggest metronidazole as first-line therapy in mild to moderately severe CDI and oral vancomycin in individuals with severe CDI, or when metronidazole fails or is contradicted. Alterations of the colonic microbiota, usually caused by antimicrobial therapy, seem to play a critical role in CDI… CONTINUE READING