Probiotics as beneficial agents in the management of diabetes mellitus: a systematic review

  title={Probiotics as beneficial agents in the management of diabetes mellitus: a systematic review},
  author={Elham Razmpoosh and Maryam Javadi and Hanieh-Sadat Ejtahed and Parvin Mirmiran},
  journal={Diabetes/Metabolism Research and Reviews},
  pages={143 - 168}
Probiotics have been suggested to play an important role in the management of diabetes. We conducted a systematic review on the role of probiotics in modulating parameters related to diabetes in animal and human experiments. We searched Pubmed, Scopus and Cochrane central until June 2014, concerning the effects of probiotics on hyperglycemia, hyperinsulinemia and their anti‐diabetic efficacies by modulating the activities of proinflammatory and antioxidant factors. Our initial search retrieved… 

Efficacy of probiotic supplement for gestational diabetes mellitus: a systematic review and meta-analysis

  • J. PanQiangwei PanYumei ChenHongping ZhangXiaodong Zheng
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2019
Compared with control intervention in gestational diabetes mellitus, probiotic supplementation was found to significantly reduce insulin resistance (HOMA-IR) and fasting serum insulin, but had no substantial influence on fasting plasma glucose, gestational age and gestational weight.

Probiotic Mechanisms Affecting Glucose Homeostasis: A Scoping Review

In vivo and in vitro studies in English published in the last eleven years dealing with the effects of probiotics on glucose metabolism and its homeostasis were selected, summarizing their potential mechanisms.

Probiotic Soy Milk Consumption and Renal Function Among Type 2 Diabetic Patients with Nephropathy: a Randomized Controlled Clinical Trial

Overall, intake of probiotic soy milk may have a beneficial effect on the renal function in patients with DN.

The effects of probiotic supplement on hemoglobin in chronic renal failure patients under hemodialysis: A randomized clinical trial

Similar studies are recommended to be conducted with a prolonged duration of the study or an increased probiotic dose with larger sample size to complete the results of the present study.

Microbiota as a Target in the Pathogenesis of Metabolic Disorders : A New Approach to Novel Therapeutic

In this review, insights are provided into the role of the gut microbiota in metabolic disorders and its modulating interventions such as prebiotics, probiotics, and fecal microbiota transplantation.

Nigerian foods of probiotics relevance and chronic metal exposure: a systematic review

Consumption of Nigerian fermented foods may hold a promise in checking the high body burden of heavy metals in Nigeria and studies from some African countries suggest that fermented foods of probiotics relevance have effectively shown metal chelation properties.

The Activity of Prebiotics and Probiotics in Hepatogastrointestinal Disorders and Diseases Associated with Metabolic Syndrome

The role of prebiotics, probiotics, or symbiotic complexes has been extensively evaluated and the results are favorable, showing that they play a crucial role in the regulation of the immune system, the metabolism of carbohydrates and lipids, and the biotransformation of bile acids.



Role of probiotics in modulating glucose homeostasis: evidence from animal and human studies

Inflammatory markers and lipid profile were significantly improved in the animal model, while data from human studies were controversial, so well-designed placebo-controlled clinical trials with validated outcome variables are needed to determine the effect of probiotics on glucose homeostasis.

Effects of probiotic yogurt consumption on inflammatory biomarkers in patients with type 2 diabetes

It is suggested that probiotic yogurt may be used as an alternative prevention approach and treatment method to control diabetic complications.


Considering the positive effect of probiotic yoghurt in reducing fasting blood sugar in type 2 diabetic patients, consumption of probiotics is recommended as auxiliary therapy in these patients.

Probiotics: a potential role in the prevention of gestational diabetes?

Probiotics offer the tantalising possibility of a feasible intervention for the prevention of gestational diabetes and improvement of metabolic syndromes, but there is a pressing need for further studies of the mechanisms underlying the apparent metabolic benefits and for the use of randomised controlled trials to allow examination of the effectiveness of probiotic supplementation.

Effect of Probiotics on Lipid Profile, Glycemic Control, Insulin Action, Oxidative Stress, and Inflammatory Markers in Patients with Type 2 Diabetes: A Clinical Trial

The result of this study indicates a non- significant declining trend in the level of TG, MDA and IL-6 and insulin resistance after consumption of probiotics.

Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects

Insulin sensitivity was preserved among volunteers in the L. acidophilus NCFM group, whereas it decreased in the placebo group, and the systemic inflammatory response were, however, unaffected by the intervention.

Effect of Multispecies Probiotic Supplements on Metabolic Profiles, hs-CRP, and Oxidative Stress in Patients with Type 2 Diabetes

In conclusion, multispecies probiotic supplementation, compared with placebo, for 8 weeks in diabetic patients prevented a rise in FPG and resulted in a decrease in serum hs-CRP and an increase in plasma total GSH.

Probiotics to Adolescents With Obesity: Effects on Inflammation and Metabolic Syndrome

It was not possible to detect any beneficial effect of the probiotic intervention with Ls-33 on inflammatory markers or parameters related to the MS in adolescents with obesity being in a state of low-grade systemic inflammation.

Cholesterol-Lowering Effects of Probiotics and Prebiotics: A Review of in Vivo and in Vitro Findings

  • L. OoiM. Liong
  • Biology
    International journal of molecular sciences
  • 2010
Past in vivo studies showed that the administration of probiotics and/or prebiotics are effective in improving lipid profiles, including the reduction of serum/plasma total cholesterol, LDL-ch cholesterol and triglycerides or increment of HDL-cholesterol, but more clinical evidence is needed to strengthen these proposals.