Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease.

@article{Li2003ProbioticsAA,
  title={Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease.},
  author={Zhiping Li and Shiqi Yang and Huizhi Lin and Jiawen Huang and Paul A. Watkins and Ann Moser and Claudio Desimone and Xiao-yu Song and Anna Mae Diehl},
  journal={Hepatology},
  year={2003},
  volume={37 2},
  pages={343-50}
}
Ob/ob mice, a model for nonalcoholic fatty liver disease (NAFLD), develop intestinal bacterial overgrowth and overexpress tumor necrosis factor alpha (TNF-alpha). In animal models for alcoholic fatty liver disease (AFLD), decontaminating the intestine or inhibiting TNF-alpha improves AFLD. Because AFLD and NAFLD may have a similar pathogenesis, treatment with a probiotic (to modify the intestinal flora) or anti-TNF antibodies (to inhibit TNF-alpha activity) may improve NAFLD in ob/ob mice. To… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS