Probiotics Reduce Gut Microbial Translocation and Improve Adult Atopic Dermatitis

  title={Probiotics Reduce Gut Microbial Translocation and Improve Adult Atopic Dermatitis},
  author={Enrico Iemoli and Daria Trabattoni and Serena Parisotto and Linda Borgonovo and Marco Toscano and Giuliano Rizzardini and Mario Clerici and Elena Ricci and A. Fusi and Elena De Vecchi and Stefania Piconi and Lorenzo Drago},
  journal={Journal of Clinical Gastroenterology},
Background: It has been suggested that probiotics modulate atopic dermatitis (AD) progression, but no data are actually available on their mechanisms of action and on their ability to act as immunomodulators in this pathology. Objective: The aim of this randomized double-blinded active treatment versus placebo study was to evaluate clinical efficacy of an intake of a combination of 2 probiotics (Lactobacillus salivarius LS01 and Bifidobacterium breve BR03) for the treatment of adult AD patients… 
Beneficial effect of Lactobacillus plantarum IS-10506 supplementation in adults with atopic dermatitis: a randomized controlled trial
The administration of LP IS-10506 is effective for alleviating AD symptoms in adults owing to its immunomodulatory effects.
Effects of probiotics for the treatment of atopic dermatitis: a meta-analysis of randomized controlled trials.
Effect of Oral Administration of a Mixture of Probiotic Strains on SCORAD Index and Use of Topical Steroids in Young Patients With Moderate Atopic Dermatitis: A Randomized Clinical Trial
The mixture of probiotics was effective in reducing SCORAD index and reducing the use of topical steroids in patients with moderate atopic dermatitis in a 12-week randomized, double-blind, placebo-controlled intervention trial.
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There is currently little reliable scientific data that supports the theory that there exists a cause–effect relationship between taking probiotics and alleviation of allergic disease, and these findings are too variable to allow substantial conclusions as to the efficacy and effectiveness of probiotic use in these disease states.
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This review considered the impact of gastrointestinal microbiota on the psoriasis pathogenesis, and through literature survey, attempted to explore probiotic species utilized for Psoriasis treatment.
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A growing number of studies support probiotic therapy to prevent or treat gingivitis and periodontitis and oral administration of probiotics is an effective adjunct in reducing pathogenic bacteria and improving clinical signs of disease.
Probiotic supplements might not be universally-effective and safe: A review.
Lactobacillus plantarum NCIMB8826 ameliorates inflammation of colon and skin in human APOC1 transgenic mice.
Modulation of intestinal immune homeostasis contributes to the suppression of atopic dermatitis in hyperlipidemic human APOC1(+/+) mice.
The Association of Bifidobacterium breve BR03 and B632 is Effective to Prevent Colics in Bottle-fed Infants: A Pilot, Controlled, Randomized, and Double-Blind Study
The evidence of the usefulness of some probiotic strains in the treatment and prevention of infant colics is growing, and therefore their use in clinical practice is spreading.


Therapeutic Effects of Probiotics in Patients with Atopic Dermatitis
The results suggest that the treatment with the mixture of four probiotic strains is beneficial for the management of the adolescent and adult AD patients, as well as for the childhood AD patients.
Clinical Effects of Probiotic Bifidobacterium breve Supplementation in Adult Patients with Atopic Dermatitis
The results suggest that B. breve may be beneficial for the treatment of atopic dermatitis, however, since the severity of disease symptoms in the placebo group at the beginning of the study was milder than those in the probiotic group, further study is needed to determine the clinical value of B. Breve.
Effects of Lactobacillus Salivarius LS01 (DSM 22775) Treatment on Adult Atopic Dermatitis: A Randomized Placebo-Controlled Study
In this study, the administration of L. salivarius LS01 was well tolerated and was associated with a significant improvement of clinical manifestation and QoL and could be considered as an important adjunctive therapy in the treatment of adult AD.
Probiotics for the Treatment or Prevention of Atopic Dermatitis
Probiotics, especially L. rhamnosus GG, seem to be effective for the prevention of AD, and were found to reduce the severity of AD in approximately half of the RCTs evaluated, although they were not found to change significantly most of the inflammatory markers measured in the majority of theRCTs evaluation.
Probiotics in Allergy Management
  • J. Vanderhoof
  • Medicine, Biology
    Journal of pediatric gastroenterology and nutrition
  • 2008
In conclusion, probiotics are effective in the treatment and/or prevention of a number of conditions, including diarrhoea, irritable bowel syndrome and atopic dermatitis, and the product used should be selected based on the particular indication.
Successful management of mild atopic dermatitis in adults with probiotics and emollients
It is demonstrated that regular use of probiotics with antioxidative properties coupled with the use of lipid-containing emollients considerably decreases inflammation and concomitant oxidative stress in adult patients with mild-to-moderate atopic dermatitis.
The Rationale and Clinical Effectiveness of Probiotics in Irritable Bowel Syndrome
The rationale for targeting the intestinal microbiota in patient with IBS is discussed and an overview and a critical evaluation of the currently available clinical data on the use of probiotics in the treatment of patientswith IBS are provided.
Probiotic-induced changes in the intestinal epithelium: implications in gastrointestinal disease.
  • B. Ramakrishna
  • Biology, Medicine
    Tropical gastroenterology : official journal of the Digestive Diseases Foundation
  • 2009
The effects of probiotic bacteria on the intestinal epithelium and their downstream consequences are reviewed, with implications for the treatment of several gastrointestinal diseases including antibiotic-associated colitis, acute gastroenteritis, inflammatory bowel disease, colon cancer, and irritable bowel syndrome.