Probiotic genomic DNA reduces the production of pro-inflammatory cytokine tumor necrosis factor-alpha.

Abstract

The effect of Lactobacillus plantarum genomic DNA on lipopolysaccharide (LPS)-induced mitogen-activated protein kinase (MAPK) activation, nuclear factor-kappa B activation, and the expressions of tumor necrosis factor-alpha, interleukin-1 receptor-associated kinase M, and the pattern recognition receptor were examined. Pretreatment of p-gDNA inhibited the phosphorylation of MAPKs and nuclear factor-kappa B, and also inhibited LPS-induced TNF-α production in response to subsequent LPS stimulation. L. plantarum genomic DNA-mediated inhibition of signaling pathway and tumor necrosis factor-alpha was accompanied by the suppression of toll-like receptor (TLR) 2, TLR4, and TLR9 and the induction of interleukin-1 receptor-associated kinase M, a negative regulator of TLR. This study can extend our understanding of the biological function of probiotic genomic DNA as an anti-inflammatory agent.

DOI: 10.1111/j.1574-6968.2011.02470.x

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@article{Kim2012ProbioticGD, title={Probiotic genomic DNA reduces the production of pro-inflammatory cytokine tumor necrosis factor-alpha.}, author={Chung Hee Kim and Han Geun Kim and Joo Yun Kim and Na Ra Kim and Bong Jun Jung and Ji Hye Jeong and Dae Kyun Chung}, journal={FEMS microbiology letters}, year={2012}, volume={328 1}, pages={13-9} }