Probiotic Therapy: Immunomodulating Approach Toward Urinary Tract Infection

@article{Amdekar2011ProbioticTI,
  title={Probiotic Therapy: Immunomodulating Approach Toward Urinary Tract Infection},
  author={Sarika Amdekar and Vinod Kumar Singh and Desh Deepak Singh},
  journal={Current Microbiology},
  year={2011},
  volume={63},
  pages={484-490}
}
Urinary tract infection (UTI) is an extremely common health problem, with an unpredictable history. Members of enterobacteriaceae family such as Escherichia coli, which are normal inhabitants of human intestines, account for the majority of these uncomplicated infections. Rarely, UTI can result from virus or fungus. There is a close correlation between loss of the normal genital microbiota, particularly Lactobacillus species, and an increased incidence of genital and bladder infections… 

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References

SHOWING 1-10 OF 75 REFERENCES

Potential preventive strategies and therapies in urinary tract infection

  • G. Reid
  • Biology
    World Journal of Urology
  • 1999
The next decade should see the introduction of new methods for reduction of the high incidence of UTI and better management of recurring urogenital infections.

Prevention and treatment of urinary tract infection with probiotics: Review and research perspective

The spiralling costs of antibiotic therapy, the appearance of multiresistant bacteria and more importantly for patients and clinicians, unsatisfactory therapeutic options in recurrent urinary tract

Microbial Ecology and Probiotics in Human Medicine (Part II)

In vivo studies might reveal additional conditions which will benefit by the correct use of probiotics, which have been used successfully to facilitate treatment of bacterial vaginosis, recurrent urinary tract infections, diarrhea, bladder cancer, complications of antibiotics, dysbacteriosis, and dyslipidemias.

Pathogenesis of urinary tract infections with normal female anatomy.

Prevention of urinary tract infection in rats with an indigenous Lactobacillus casei strain

The results show that L. casei prevented onset of urinary tract infection in 84% of the animals tested, and it is hoped that the demonstration of a protective role for indigenous bacteria in preventing urinary tract infections in an animal model will lead to the application of this technology to prevent recurrent urinary tract infected patients.

Uropathogenic Escherichia coli as a model of host-parasite interaction.

Functional modulation of enterocytes by gram-positive and gram-negative microorganisms.

  • J. OtteD. Podolsky
  • Biology
    American journal of physiology. Gastrointestinal and liver physiology
  • 2004
Probiotics and protein(s) released by these organisms may functionally modulate the intestinal epithelium of the host by different mechanisms, including the competition of whole organisms for contact with the epithelial surface as well as stabilization of the cytoskeleton and barrier function and the induction of mucin expression.

Bacterial virulence in urinary tract infection.

This review attempts to summarize the mechanisms known to contribute to bacterial virulence in the urinary tract and their relevance in different patient groups.

Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 May Help Downregulate TNF-Alpha, IL-6, IL-8, IL-10 and IL-12 (p70) in the Neurogenic Bladder of Spinal Cord Injured Patient with Urinary Tract Infections: A Two-Case Study

It is hypothesized that members of the commensal flora, such as lactobacilli, may counter this reaction through anti-inflammatory mediation, and this was assessed in a pilot two-patient study, which resulted in improved well-being in spinal cord injured patients.

Increasing antimicrobial resistance in Escherichia coli isolates from community-acquired urinary tract infections during 1998-2003 in Manisa, Turkey.

The aim of this study was to determine the change in antimicrobial susceptibility of Escherichia coli isolates from patients with community-acquired urinary tract infection (UTI) for the years 1998 through 2003 and to suggest that the current empirical antibiotic therapy used for these patients is inappropriate.
...