Probiotic Lactobacillus acidophilus enhances the immunogenicity of an oral rotavirus vaccine in gnotobiotic pigs.

@article{Zhang2008ProbioticLA,
  title={Probiotic Lactobacillus acidophilus enhances the immunogenicity of an oral rotavirus vaccine in gnotobiotic pigs.},
  author={Wei Zhang and Marli S P Azevedo and Ke Wen and Ana Maria Gonzalez and Linda J. Saif and Guohua Li and Ahmed Yousef and Lijuan Yuan},
  journal={Vaccine},
  year={2008},
  volume={26 29-30},
  pages={3655-61}
}
We evaluated virus-specific B and T cell responses induced by the attenuated Wa (P1A[8]G1) human rotavirus (AttHRV) oral 2-dose vaccine with or without Lactobacillus acidophilus (LA) colonization in neonatal gnotobiotic (Gn) pigs. The AttHRV vaccinated and LA-fed pigs had a significantly higher magnitude of HRV-specific IFN-gamma producing CD8+ T cell responses in ileum and spleen, IgA and IgG antibody-secreting cell responses in ileum, and serum IgM, IgA and IgG antibody and virus neutralizing… CONTINUE READING

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