Probiotic Bacillus amyloliquefaciens mediate M1 macrophage polarization in mouse bone marrow-derived macrophages

@article{Ji2013ProbioticBA,
  title={Probiotic Bacillus amyloliquefaciens mediate M1 macrophage polarization in mouse bone marrow-derived macrophages},
  author={Jian Ji and Sheng-Lan Hu and Zhi-Wen Cui and Wei-fen Li},
  journal={Archives of Microbiology},
  year={2013},
  volume={195},
  pages={349-356}
}
Depending on the microenvironment, macrophages can acquire distinct functional phenotypes, referred to as classically activated M1 and M2. M1 macrophages are considered potent effector cells that kill intracellular pathogens, and M2 macrophages promote the resolution of wound healing. In this study, we are interested to know whether probiotic Bacillus amyloliquefaciens (Ba) can induce macrophages polarization. Real-time fluorescence PCR analysis demonstrated that the expression of IL-1β, iNOS… CONTINUE READING

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