Probing transport of charged β-lactamase inhibitors through OmpC, a membrane channel from E. coli.

Abstract

One of the major causes of antibiotic resistance in the Gram-negative bacteria is the low permeability across the outer membrane. Currently a main bottleneck in the development of effective antibiotics is the lack of a general method to quantify permeation which would allow screening for optimal scaffolds. Here, we present a permeation assay based on… (More)
DOI: 10.1016/j.bbrc.2017.01.076

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Cite this paper

@article{Ghai2017ProbingTO, title={Probing transport of charged β-lactamase inhibitors through OmpC, a membrane channel from E. coli.}, author={Ishan Ghai and Mathias Winterhalter and Richard Wagner}, journal={Biochemical and biophysical research communications}, year={2017}, volume={484 1}, pages={51-55} }