Probing the yeast phase-specific expression of the CBP1 gene in Histoplasma capsulatum.

@article{Patel1998ProbingTY,
  title={Probing the yeast phase-specific expression of the CBP1 gene in Histoplasma capsulatum.},
  author={Jignesh Bharatbhai Patel and J W Batanghari and William E Goldman},
  journal={Journal of bacteriology},
  year={1998},
  volume={180 7},
  pages={
          1786-92
        }
}
Histoplasma capsulatum is a pathogenic fungus that exists in two distinct forms. The saprophytic mycelial phase inhabits moist soil environments; once inhaled, hyphae and conidia convert to a unicellular yeast phase that is capable of parasitizing macrophage phagolysosomes. Yeasts cultures, but not mycelial cultures, release large quantities of a calcium-binding protein (CBP) which may be important in calcium acquisition during intracellular parasitism. In this study, we show that the gene… CONTINUE READING

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