Probing the substrate specificity of the dengue virus type 2 NS3 serine protease by using internally quenched fluorescent peptides.

@article{Niyomrattanakit2006ProbingTS,
  title={Probing the substrate specificity of the dengue virus type 2 NS3 serine protease by using internally quenched fluorescent peptides.},
  author={Pornwaratt Niyomrattanakit and Sviatlana Yahorava and Ilze Mutule and Felikss Mutulis and Ramona Petrovska and Peteris Prusis and Gerd R Katzenmeier and Jarl E. S. Wikberg},
  journal={The Biochemical journal},
  year={2006},
  volume={397 1},
  pages={203-11}
}
The NS3 (dengue virus non-structural protein 3) serine protease of dengue virus is an essential component for virus maturation, thus representing an attractive target for the development of antiviral drugs directed at the inhibition of polyprotein processing. In the present study, we have investigated determinants of substrate specificity of the dengue virus NS3 protease by using internally quenched fluorogenic peptides containing Abz (o-aminobenzoic acid; synonymous to anthranilic acid) and 3… CONTINUE READING
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