Probing the structural requirements of A-type Aurora kinase inhibitors using 3D-QSAR and molecular docking analysis.

@article{Zhang2012ProbingTS,
  title={Probing the structural requirements of A-type Aurora kinase inhibitors using 3D-QSAR and molecular docking analysis.},
  author={Hui-xiao Zhang and Yan Li and Xia Wang and Yonghua Wang},
  journal={Journal of molecular modeling},
  year={2012},
  volume={18 3},
  pages={1107-22}
}
Aurora-A, the most widely studied isoform of Aurora kinase overexpressed aberrantly in a wide variety of tumors, has been implicated in early mitotic entry, degradation of natural tumor suppressor p53 and centrosome maturation and separation; hence, potent inhibitors of Aurora-A may be therapeutically useful drugs in the treatment of various forms of cancer… CONTINUE READING