Probing the role of homomeric and heteromeric receptor interactions in TGF-β signaling using small molecule dimerizers

  title={Probing the role of homomeric and heteromeric receptor interactions in TGF-β signaling using small molecule dimerizers},
  author={B. Stockwell and S. Schreiber},
  journal={Current Biology},
  • B. Stockwell, S. Schreiber
  • Published 1998
  • Biology, Medicine
  • Current Biology
  • BACKGROUND Transforming growth factor Beta (TGF-Beta) arrests many cell types in the G1 phase of the cell and upregulates plasminogen activator inhibitor 1 (PAI-1). The type 1 (TGF-Beta RI) an II (TGF-Beta RII) TGF-Beta receptors mediate these and other effects of TGF-Beta on target cells. TGF-Beta initially binds to TGF-Beta RII and subsequently TGF-Beta RI is recruited to form a heteromeric complex. TGF-Beta RI phosphorylates the downstream effectors Smad2 and Smad3, leading to their… CONTINUE READING
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