Probing the role of homomeric and heteromeric receptor interactions in TGF-β signaling using small molecule dimerizers
@article{Stockwell1998ProbingTR, title={Probing the role of homomeric and heteromeric receptor interactions in TGF-β signaling using small molecule dimerizers}, author={B. Stockwell and S. Schreiber}, journal={Current Biology}, year={1998}, volume={8}, pages={761-773} }
BACKGROUND
Transforming growth factor Beta (TGF-Beta) arrests many cell types in the G1 phase of the cell and upregulates plasminogen activator inhibitor 1 (PAI-1). The type 1 (TGF-Beta RI) an II (TGF-Beta RII) TGF-Beta receptors mediate these and other effects of TGF-Beta on target cells. TGF-Beta initially binds to TGF-Beta RII and subsequently TGF-Beta RI is recruited to form a heteromeric complex. TGF-Beta RI phosphorylates the downstream effectors Smad2 and Smad3, leading to their… CONTINUE READING
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