Probing the role of E272 in quinol oxidation of mitochondrial complex III.

@article{Wenz2006ProbingTR,
  title={Probing the role of E272 in quinol oxidation of mitochondrial complex III.},
  author={Tina Wenz and Petra Hellwig and Fraser Macmillan and Brigitte Meunier and Carola Hunte},
  journal={Biochemistry},
  year={2006},
  volume={45 30},
  pages={9042-52}
}
Bifurcated electron transfer during ubiquinol oxidation is the key reaction of complex III catalysis, but the molecular basis of this process is still not clear. E272 of the conserved cytochrome b PEWY motif has been suggested as a ligand and proton acceptor for ubiquinol oxidation at center P. We introduced the two replacement mutations, E272D and E272Q, into the mitochondrially encoded cytochrome b gene by biolistic transformation to study their effects on substrate binding and catalysis… CONTINUE READING

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