Probing the origin of matching functional jaws: roles of Dlx5/6 in cranial neural crest cells

@article{Shimizu2018ProbingTO,
  title={Probing the origin of matching functional jaws: roles of Dlx5/6 in cranial neural crest cells},
  author={Miki Shimizu and Nicolas Narboux-N{\^e}me and Yorick Gitton and Camille de Lombares and Anastasia Fontaine and Gladys Alfama and Taro Kitazawa and Yumiko K Kawamura and {\'E}glantine Heude and Lindsey Marshall and Hiroki Higashiyama and Youichiro Wada and Yukiko Kurihara and Hiroki Kurihara and Giovanni Levŕ},
  journal={Scientific Reports},
  year={2018},
  volume={8}
}
Gnathostome jaws derive from the first pharyngeal arch (PA1), a complex structure constituted by Neural Crest Cells (NCCs), mesodermal, ectodermal and endodermal cells. Here, to determine the regionalized morphogenetic impact of Dlx5/6 expression, we specifically target their inactivation or overexpression to NCCs. NCC-specific Dlx5/6 inactivation (NCC∆Dlx5/6) generates severely hypomorphic lower jaws that present typical maxillary traits. Therefore, differently from Dlx5/6 null-embryos, the… 
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