Probing the nanoscale viscoelasticity of intracellular fluids in living cells.

@article{Guigas2007ProbingTN,
  title={Probing the nanoscale viscoelasticity of intracellular fluids in living cells.},
  author={Gernot Guigas and Claudia Kalla and Matthias Weiss},
  journal={Biophysical journal},
  year={2007},
  volume={93 1},
  pages={316-23}
}
We have used fluorescence correlation spectroscopy to determine the anomalous diffusion properties of fluorescently tagged gold beads in the cytoplasm and the nucleus of living cells. From the extracted mean-square displacement v(tau) approximately tau(alpha), we have determined the complex shear modulus G(omega) approximately omega(alpha) for both compartments. Without treatment, all tested cell lines showed a strong viscoelastic behavior of the cytoplasm and the nucleoplasm, highlighting the… CONTINUE READING

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