Probing the molecular dynamics of the ABC multidrug transporter LmrA by deuterium solid-state nuclear magnetic resonance.

@article{Siarheyeva2007ProbingTM,
  title={Probing the molecular dynamics of the ABC multidrug transporter LmrA by deuterium solid-state nuclear magnetic resonance.},
  author={Alena Siarheyeva and Jakob J. Lopez and Ines Lehner and Ute A Hellmich and Hendrik W van Veen and Clemens Glaubitz},
  journal={Biochemistry},
  year={2007},
  volume={46 11},
  pages={3075-83}
}
The molecular dynamics of the 64 kDa ABC multidrug efflux pump LmrA from Lactococcus lactis within lipid membranes has been investigated by deuterium solid-state NMR. Deuteriomethyl-labeled alanine has been used to probe global protein backbone dynamics. A comparison of static deuterium NMR spectra of full-length LmrA in the resting state and its isolated… CONTINUE READING