Probing the kinetics of beta-amyloid self-association.

Spontaneous conversion of beta-amyloid peptide (Abeta) from soluble monomer to insoluble fibrillar precipitate may underlie the neurodegeneration associated with Alzheimer's disease. A complete description of Abeta self-association kinetics requires identification of the oligomeric species present and the pathway of association, as well as quantitation of… (More)