Probing the immunological properties of the extracellular domains of the human beta(1)-adrenoceptor.

@article{Mobini1999ProbingTI,
  title={Probing the immunological properties of the extracellular domains of the human beta(1)-adrenoceptor.},
  author={Reza Mobini and Yvonne Magnusson and Gert Wallukat and M Viguier and Ake Hjalmarson and Johan Hoebeke},
  journal={Journal of autoimmunity},
  year={1999},
  volume={13 2},
  pages={
          179-86
        }
}
The human beta(1)-adrenoceptor is an immune target for autoantibodies with functional activity in cardiovascular diseases. Different epitopes on the extracellular domains of the receptor are involved. To study the immunological and pharmacological properties of these epitopes, rabbits were immunized with peptides corresponding to a large domain in the N-terminal part of the receptor and to its first and second extracellular loops. In contrast to the two other peptides, the first extracellular… CONTINUE READING

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