Probing the hexosamine biosynthetic pathway in human tumor cells by multitargeted tandem mass spectrometry.

@article{Rahman2013ProbingTH,
  title={Probing the hexosamine biosynthetic pathway in human tumor cells by multitargeted tandem mass spectrometry.},
  author={Anas M. Abdel Rahman and Michael C. Ryczko and Judy Pawling and J. W. Dennis},
  journal={ACS chemical biology},
  year={2013},
  volume={8 9},
  pages={2053-62}
}
Cancer progression is accompanied by increases in glucose and glutamine metabolism, providing the carbon and nitrogen required in downstream anabolic pathways. Fructose-6P, glutamine, and acetyl-CoA are central metabolites and substrates of the hexosamine biosynthesis pathway (HBP) to UDP-N-acetylglucosamine (UDP-GlcNAc), an essential high-energy donor for… CONTINUE READING

Topics

Statistics

0102030201620172018
Citations per Year

Citation Velocity: 12

Averaging 12 citations per year over the last 3 years.

Learn more about how we calculate this metric in our FAQ.