Probing the functional link between androgen receptor coactivator and ligand-binding sites in prostate cancer and androgen insensitivity.


The androgen receptor (AR) is a ligand-activated transcription factor required for male sex development and virilization and contributes to prostate cancer initiation and progression. High affinity androgen binding triggers conformational changes required for AR transactivation. Here we characterized naturally occurring AR gene mutations in the region of… (More)


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