Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis.

@article{Reisinger2011ProbingTF,
  title={Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis.},
  author={Ellen Reisinger and Chris S. Bresee and Jakob Neef and Ramya Nair and Kirsten Reuter and Anna V. Bulankina and R{\'e}gis Nouvian and Manuel Koch and Johanna B{\"u}ckers and Lars Kastrup and Isabelle Roux and Christine Petit and Stefan W Hell and Nils Brose and J. T. Rhee and Sebastian K{\"u}gler and John V. Brigande and Tobias Moser},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 13},
  pages={4886-95}
}
Cochlear inner hair cells (IHCs) use Ca(2+)-dependent exocytosis of glutamate to signal sound information. Otoferlin (Otof), a C(2) domain protein essential for IHC exocytosis and hearing, may serve as a Ca(2+) sensor in vesicle fusion in IHCs that seem to lack the classical neuronal Ca(2+) sensors synaptotagmin 1 (Syt1) and Syt2. Support for the Ca(2+) sensor of fusion hypothesis for otoferlin function comes from biochemical experiments, but additional roles in late exocytosis upstream of… CONTINUE READING