Probing the dynamic organization of transcription compartments and gene loci within the nucleus of living cells.

Abstract

The three-dimensional organization of nuclear compartments within living cells determines genome function and yet their underlying self-organizing principles are unclear. We visualize in real-time transcriptionally active compartments (TCs) by the transient enrichment of fluorescently-labeled uridine 5'-triphosphate molecules within living cells. These TCs… (More)
DOI: 10.1529/biophysj.108.135921

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