Probing the compatibility of type II ketosynthase-carrier protein partners.

  title={Probing the compatibility of type II ketosynthase-carrier protein partners.},
  author={Andrew S Worthington and G. H. Hur and Jordan L Meier and Qian Cheng and Bradley S Moore and Michael D. Burkart},
  journal={Chembiochem : a European journal of chemical biology},
  volume={9 13},
Drug discovery often begins with the screening of large compound libraries to identify lead compounds. Recently, the enzymes that are involved in the biosynthesis of natural products have been investigated for their potential to generate new, diverse compound libraries. There have been several approaches toward this end, including altering the substrate specificities of the enzymes involved in natural product biosynthesis and engineering functional communication between enzymes from different… CONTINUE READING

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