Probing the anticancer mechanism of prospective herbal drug Withaferin A on mammals: a case study on human and bovine proteasomes

@article{Grover2010ProbingTA,
  title={Probing the anticancer mechanism of prospective herbal drug Withaferin A on mammals: a case study on human and bovine proteasomes},
  author={A. Grover and Ashutosh Shandilya and V. Bisaria and D. Sundar},
  journal={BMC Genomics},
  year={2010},
  volume={11},
  pages={S15 - S15}
}
BackgroundThe UPP (ubiquitin proteasome pathway) is the major proteolytic system in the cytosol and nucleus of all eukaryotic cells which regulates cellular events, including mitotis, differentiation, signal transduction, apoptosis, and inflammation. UPP controls activation of the transcriptional factor NF-κB (nuclear factor κB), which is a regulatory protein playing central role in a variety of cellular processes including immune and inflammatory responses, apoptosis, and cellular… Expand
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